Adiponectin Provides Cardiovascular Protection in Metabolic Syndrome

Adiponectin Provides Cardiovascular Protection in Metabolic Syndrome

Adipose tissue plays a central role in the pathogenesis of metabolic syndrome. Adiponectin (APN) is a bioactive adipocytokine secreted from adipocytes. Low plasma APN levels (hypoadiponectinemia) are observed among obese individuals and in those with related disorders such as diabetes, hypertension, and dyslipidemia. APN ameliorates such disorders. Hypoadiponectinemia is also associated with ma...

Adiponectin and metabolic syndrome.

In this review article, the crucial roles of adipocytes in the development of so-called metabolic syndrome and vascular disease are reviewed, focusing on adipocyte-derived bioactive substances, adipocytokines. Recent progress in adipocyte biology shows that adipocytes are not merely energy-storing cells but that they secrete a variety of hormones cytokines, growth factors, and other bioactive s...

Role of adiponectin in cardiovascular protection.

therosclerosis is a pathological injury-to-response process that is initiated by early inflammatory responses of vascular endothelial cells. Endothelial inflammation is characterized by decreased nitric oxide (NO) formation, platelet adherence to endothelium, monocyte adhesion and migration into the neointima lesion, followed by transformation of macrophages into foam cells. Subsequently, oxidi...

Adiponectin: an adipokine with protective features against metabolic syndrome

Metabolic syndrome (MetS) as a collection of obesity-associated disorders is associated with inflammation, oxidative stress, pro-thrombotic state, elevated risk of developing cardiovascular disease and type 2 diabetes. Adiponectin is one of the most abundant peptide hormones derived from adipose tissue. This protein plays a major role in glucose and lipid metabolism and prevents development of ...

adiponectin and metabolic syndrome prevention